This pathway’s critical regulators, including p-Akt and p-mTOR, were found to be significantly elevated in both OLP lesions and local T cells in a ground-breaking study conducted by Zhang et al. This suggests that activated Akt/mTOR autophagy may be a key factor in the local T cell-mediated immune regulatory mechanism of OLP [32]. The gene discussed is AKT1; the disease is oral lichen planus.