Premature fusion of cranial sutures is most often associated with Apert syndrome (FGFR2), Muenke syndrome (FGFR3), Crouzon syndrome (FGFR2), Pfeiffer syndrome (FGFR2, FGFR1), and Saethre-Chotzen syndrome (TWIST1) [30]. The gene discussed is TWIST1; the disease is Apert syndrome.