PRKAG2 and metabolic disease: Genes like TTR, PRKAG2, LAMP2, GLA, and GAA are associated with metabolic disorders that resemble HCM, but their clinical profiles, inheritance patterns, and treatments differ from one another and from HCM [75] regarding different modes of inheritance (Fabry and Danon disease are X-linked), distinct progression (accelerated systolic dysfunction in Danon disease), distinct complications (conduction defects in PRKAG2 disease), and specific therapeutics (enzyme replacement treatment in Fabry or Pompe disease) [73,74].