GPX3 and Balkan nephropathy: Furthermore, female patients who carried both GPX3 and MDR1 variant genotypes (GPX3*TC*CC genotype and MDR1*CT*TT genotype) were at a higher risk of BEN development (OR 1 = 3.34, 95% CI = 1.16–9.60, p = 0.025), which was confirmed in the adjusted model (OR 2 = 3.79, 95% CI = 1.27–11.24, p = 0.016) (Table 4).