When GPX3 and MDR1-variant genotypes were combined a certain statistically insignificant risk on BEN development was observed (OR 1 = 1.75, 95% CI = 0.86–3.55, p = 0.117; OR 2 = 1.86, 95% CI = 0.91–3.80, p = 0.087). This evidence concerns the gene GPX3 and Balkan nephropathy.