The PPIN analysis revealed ESR1, ESR2, PGR, EGFR, IGF1R, FGFR1, KIT, PTEN, mTOR, NOTCH 1, NOTCH 4, NFkB, CCND1, VEGFR3, LRP6, and APC (Table 1) as the candidate genes possessing the triple-negative breast cancer-specific functions and mechanisms. The gene discussed is ESR1; the disease is triple-negative breast carcinoma.