TMEM67 and nutritional deficiency disease: Hence, it is necessary to carry out more toxicity studies to truly ensure that DL-HEPB does not show dose-associated alterations, if it acts at the level of the TMEM67 protein, or if these alterations are related to a nutritional deficiency driven by the decrease in food consumption, etc. For the aforementioned, the significance of this study lies in the need to develop new anticonvulsant molecules with less toxic effects for embryo-fetal development.