The expression of lipocalin-2 was reduced in 3T3-L1 MBX cells cultured with the fatty acids cocktail, in contrast to the observations reported from previous studies where it has been demonstrated to have a link between the increased expression of lipocalin 2 with insulin resistance, obesity, and hyperglycemic conditions [54,55,56]. This evidence concerns the gene LCN2 and obesity due to melanocortin 4 receptor deficiency.