INS and obesity due to melanocortin 4 receptor deficiency: In addition to that, due to other complex pathophysiological consequences of obesity (i.e., changes in the gut microbiome, insulin resistance, oxidative stress, and inflammation), a susceptibility to develop different comorbid, diseased conditions such as Type-2 diabetes mellitus, cancer (liver, colon, breast, ovary, prostate), fatty liver, hypertension, Alzheimer disease, depression, and asthma, increases [1,6,7,8].