Chimeric mice with HIF-1α-deficient B and T cells showed increased tissue damage and autoimmunity, and mice with conditional knockout of HIF-1α in granulocytes, monocytes and macrophages showed impaired myeloid cell infiltration and activation in vivo, highlighting the important role of HIF-1α in immune responses [25,46]. The gene discussed is HIF1A; the disease is Autoimmunity.