To further improve the engraftment rates, Rongvaux et al. generated immunodeficient Rag2/IL2rg−/− knockout mice with five human knock-in genes encoding macrophage colony-stimulating factor (M-CSF), interleukin-3 (IL-3), granulocyte colony-stimulating factor (G-CSF), signal regulatory protein α (SIRPα), and IL-6, which are important cytokines for innate immune cell and MM cell development [29]. This evidence concerns the gene IL3 and Miyoshi myopathy.