In 2005, researchers analyzed 2 normal skin samples, 2 benign nevi, 2 atypical nevi, 2 melanoma in situ, and 8 melanoma and observed progressive increases in PVT1 levels from normal skin and benign nevi to atypical nevi, melanoma in situ, and malignant melanoma [14]. The gene discussed is PVT1; the disease is in situ carcinoma.