A hallmark of obesity is chronic low-grade inflammation and the altered secretion of adipokines, inflammatory cytokines, and hormones, including monocyte chemotactic protein-1 (MCP-1), C-reactive protein, IL-6, tumor necrosis factor-α (TNF-α), and adiponectin [16,17]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.