Treatment with DTZ (10 mg/kg, 20 mg/kg, and 40 mg/kg, p.o.)daily for twenty-one days, 1 h before a single ICV-STZ (3 mg/kg) injection, significantly improved cognitive impairments and ameliorated the ICV-STZ-induced altered nitrite, pro-inflammatory cytokines (TNF-α, and IL-1β) and anti-oxidative enzyme levels (superoxide dismutase, lipid peroxidation, and glutathione). The gene discussed is TNF; the disease is Cognitive impairment.