DUSP6 and major depressive disorder: For example, Labonte et al. found limited overlap between transcriptional patterns in major depressive disorder (MDD) between SG and identified key regulators of sex-specific gene networks underlying MDD, including boosting ERK signaling and pyramidal neuron excitability, and downregulation of the female-specific hub gene Dusp6 in the rodent prefrontal cortex, which replicated stress vulnerability in females but not males [66].