SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Hm1a-mediated activation of Nav1.1 is able to restore the function of inhibitory interneurons from Dravet syndrome mice without affecting the activity of excitatory neurons, and intracerebroventricular infusion of Hm1a in the Dravet syndrome rodent model rescued the animals from seizures and premature death [105].