CFTR and cystic fibrosis: Follow-up recommendations included evaluation by a physician from a CF specialty center or with CF expertise, repeated sweat chloride testing at 6–12 months, close contact with a local pediatrician, clear guidance to the family with need for follow-up given the increased risk for a future diagnosis of CF or CFTR-related conditions, and annual re-evaluation of the specific CFTR variants identified in each patient [41].