Of the 10 genes, global excess bone formation is thought to be an important mechanism in the formation of DISH, GDF5 is an osteogenic protein that is associated with coronary artery disease [40], CHRDL2 is involved in diastolic blood pressure [41], and Ror2 is involved in systolic blood pressure, since many of the genetic variants associated with DISH pathogenesis are involved in circulation and metabolic dynamics such as hypertension, diabetes, and coronary artery disease, as well as bone formation [42]. The gene discussed is GDF5; the disease is diffuse idiopathic skeletal hyperostosis.