Different parameters have been used in asthma prediction models, the most important of which are age, gender, wheeze frequency, the presence of eczema, rhinitis, non-cold-related wheeze, peripheral blood eosinophilia, skin testing, specific IgE, biomarkers, gene expression, exercise-related cough/wheeze, and aeroallergen-related cough/wheeze [8]. This evidence concerns the gene IGHE and Increased total eosinophil count.