IGHE and asthma: Further investigations, such as the Avon Longitudinal Study of Parents and Children (ALSPAC) and the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) study, emphasized the association between persistent or later-resolving atopic dermatitis and an increased likelihood of coexisting asthma, high IgE levels, and familial history of atopy [29].