PLOD1 and asthma: Asthma symptoms in these patients are more intense during the perimenstrual period (also known as perimenstrual asthma) and can result in severe or difficult-to-manage asthma [10] due to decreased progesterone and testosterone levels, as well as fluctuations in estradiol, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels, which can trigger mast cell degranulation and result in a heightened respiratory response to aeroallergens [11,12,13].