LEP and obesity due to melanocortin 4 receptor deficiency: In addition to the inflammatory markers of the TH2 response, such as interleukin-4 (IL-4), IL-5, and IL-13, high levels of IL-6 and adipokines (such as leptin) due to obesity may have a synergistic effect on airway inflammation and remodeling by stimulating the accumulation of eosinophils, mast cells, and CD4+ T lymphocytes in the airway [25,26].