These histological changes are influenced by different inflammatory pathways based on the patient’s asthma phenotype, which can be identified based on a record of atopy, pulmonary symptoms, age and time of symptom onset, body mass index (BMI), Immunoglobin E serum levels (IgE), cellularity in sputum, the degree of sensitivity to aeroallergens through skin tests, the severity of airway obstruction, and the level of fractional exhaled nitric oxide (FeNO) [20,21]. Here, IGHE is linked to asthma.