A large retrospective cohort study of 2245 infertile women found that women with ASRM stage 3 or 4 endometriosis and OMA, necessitated more FSH and had a significantly lower pregnancy and live birth/ongoing pregnancy rate, compared to those with ASRM stage 3 or 4 endometriosis but without OMA [85]. This evidence concerns the gene BRD2 and endometriosis.