In addition, the involvement of Angiopoietin-2 (Ang-2), leading to vascular destabilization by inhibiting Angiopoietin-1 (Ang-1) and tyrosine kinase with immunoglobulin and epidermal growth factor homology do-mains 2 (Tie-2) signals, was actively reported in the pathogenesis of AMD, and bispecific antibodies against Ang-2 and VEGF have emerged as therapeutic agents that are attracting attention [5]. The gene discussed is ANGPT2; the disease is age-related macular degeneration.