Since the publication of the 2016 CNS WHO update, seven cIMPACT-NOW updates have reviewed newly acquired criteria on CNS tumors classification, including the definition and diagnostic pathways of NOS tumors, and the relevance of the mutations in histone 3 (K23M mutation), B-Raf (V600E mutation), and isocitrate dehydrogenase (IDH), among others [52]. Here, BRAF is linked to central nervous system neoplasm.