Furthermore, we classified the patients with monoclonal gammopathy according to the International Staging System (ISS) and Revised ISS, based on their serum levels of albumin, β2 microglobulin, and lactate dehydrogenase (LDH), and the presence of high-risk chromosomal abnormalities (CA) [33,34]. This evidence concerns the gene HLA-G and monoclonal gammopathy.