In PCOS, there are several kinds of dysfunctions of the HPO axis, such as abnormal gonadotropin-releasing hormone (GnRH) pulse frequency, elevated levels of luteinizing hormone (LH), and an imbalance in the ratio of LH/follicle-stimulating hormone (FSH), adrenal, and ovarian androgen excess [5]. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.