INSR and polycystic ovary syndrome: Genome-wide association studies identified several PCOS candidate loci: DENND1A, INSR, YAP1, C9orf3, RAB5B, HMGA2, TOX3, SUMO1P1/ZNF217, THADA, FSHR, and LHCGR from Han Chinese populations [37,38], and FSHR/LHCGR, DENND1A, RAB5B, and THADA from European populations [39].