BIN1 and Alzheimer disease: However, a meta-analysis of the top-ranked results from the discovery sample and a much larger replication sample in the Kamboh et al. GWAS (4013 cases and 4274 controls) yielded suggestive associations (p < 1 × 10−4) with SNPs in two AD loci established in EUR cohorts (BIN1 and PICALM) and association with a novel locus (PPP1R3B) [80].