GPC6 and Alzheimer disease: An ADGC GWAS by Kunkle et al. [68] that included 2784 AA AD cases and 5222 controls did not observe GWS associations with any common variants outside of the APOE region (including the ABCA7 rs115550680 SNP), although suggestive evidence of association (p < 0.05 × 10−7) was obtained for common variants in ALCAM, EDEM1, GPC6, and VRK3, as well as for a rare variant in RBFOX1.