A haplotype comprised of three SNPs towards the 3′ end of SORL1 was nominally associated with AD (p = 0.0025 with ACT haplotype derived from rs3824968, rs2282649, and rs1010159) in the AA cohort, while in the Caribbean-Hispanic cohort, association was observed with a haplotype of three SNPs located near the 5′ end of the gene (p = 0.0053 with the CGC haplotype derived from rs668387, rs689021, and rs641120). The gene discussed is SORL1; the disease is Alzheimer disease.