NOS3 and Alzheimer disease: Recognizing that vascular and inflammatory factors contribute to AD risk and the role of NOS genes in these pathways [59,60], Akomolafe et al. [61] evaluated the association of AD with the endothelial nitric oxide synthase (NOS3) Glu298Asp variant (rs1799983) and 10 other NOS variants in AA and EUR AD cases and controls from the MIRAGE Study and found a study-wide significant association with rs1799983 in the AA (p = 0.002) but not the EUR sample.