TREM2 and Alzheimer disease: Although none of the findings were significant, the top-ranked variants, one likely to be benign (rs2234256, OR = 1.27, p = 0.01) and rs2234258, which was predicted to impact the short TREM2 isoform (OR = 1.35, p = 0.08), were significantly associated with AD/ADRD in the MVP GWAS (rs2234256, p = 4.64 × 10−9 and rs2234258, p = 5.48 × 10−7) [69] and are in high LD with each other and the peak TREM2 SNPs from the Kunkle et al. GWAS (rs73427293 and rs2234253; Figure 2).