APOE and Alzheimer disease: Based on the observation that the ε4/AD association is progressively weaker in East Asian (EASN), EUR, and AA populations, respectively, Choi et al. [55] examined SNPs in the APOE region that showed a successive increase or decrease in allele frequency among 19,398 EASN individuals including Korean and Japanese participants, 15,836 EUR individuals, and 4985 AA individuals.