The analysis of the relationships between cartilage remodeling markers (C2C, PIICP, C2C/PIICP, and COMP) and demographic parameters (age and disease duration) as well as clinical (DAS28-ESR, SJC28, TJC28, and VAS) and laboratory indicators (ESR, CRP, and MMP-3) of disease activity with respect to RA patients both before and after 15 months of TNFαI therapy is presented in Table 3. The gene discussed is ESR1; the disease is rheumatoid arthritis.