In a recently published meta-analysis, the authors pooled individual-level data from seven trials: Modification of Diet in Renal Disease (MDRD), African American Study of Kidney Disease and Hypertension (AASK), Action to Control Cardiovascular Risks in Diabetes Study (ACCORD), SPRINT, Secondary Prevention of Small Subcortical Strokes Trial (SPS3), Effect of Strict Blood Pressure Control and Angiotensin-Converting Enzyme Inhibition on the Progression of Chronic Renal Failure in Pediatric Patients (ESCAPE), and Ramipril Efficacy in Nephropathy-2 (REIN-2). The gene discussed is ACE; the disease is chronic kidney disease.