After multivariate cox regression adjusted for age, NT-proBNP level, right ventricular ejection fraction, and HF functional class, the impaired RA strain (p = 0.016) and strain rate (p = 0.028), as well as the impaired RA conduit strain (p = 0.019) and strain rate (p = 0.011), were still significantly related to the cardiovascular outcome (Table 3). This evidence concerns the gene NPPB and hydrops fetalis.