Tissue-specific alterations are associated with different expression profiles such as HER-2 overexpression [121], TNBC [91,133], or the stem-like profile among basal-like ductal carcinoma in situ (DCIS) tumors [134], demonstrating the possibility of modifying levels of vesicular miRNAs. This evidence concerns the gene ERBB2 and ductal breast carcinoma in situ.