In addition to conventional markers such as CD9, CD81, and CD83, the proteins HLA-A, HLA-B, HSPA5, A2M, ACTB, ALDOA, ANXA2, FN1, ANXA5, GSN, MYH9, PGK1, and ACTN1 are also often identified in EVs in cells and breast cancer patients at different stages. The gene discussed is ANXA2; the disease is breast cancer.