HGF inhibits phosphoinositide 3-kinase (PI3K) and AKT phosphorylation, activates the mTOR pathway, and inhibits the activation of NF-κB through target cellular mesenchymal–epithelial transition factor; reduces apoptosis in the liver and lung tissue; reduces the IL-1 β, IL-18, lactated hydrogenase (LDH), and ROS levels; and alleviates sepsis-induced inflammatory and oxidative stress. The gene discussed is HGF; the disease is Sepsis.