Anti-HMGB1 antibody is a monoclonal antibody developed against the inflammatory mediator HMGB1 that can regulate the levels of pro-inflammatory and anti-inflammatory factors, improve the inflammatory response in CLP mice, restore hemoglobin and hematocrit, improve anemia, enhance anti-infection ability, and reduce the mortality rate of CLP mice by 50% [60,61]. This evidence concerns the gene HMGB1 and anemia.