In sepsis, tannic acid can regulate blood pressure; reduce the expression of TNF-α, IL-6, IL-1 β and MDA in the brain tissue; upregulate the expression of γ-aminobutyric acid sub-type A receptors in the hippocampus; reduce inflammation and oxidative stress in patients with sepsis; decrease inflammation and oxidative stress in CLP rats; and improve anxiety-related behaviors in SAE rats [77]. The gene discussed is TNF; the disease is Sepsis.