HMGB1 and Sepsis: Lentinan can reduce the expression of pro-inflammatory factors, such as TNF-α, IL-1 β, IL-6, and HMGB1; improve intestinal inflammation and oxidative stress induced by sepsis; regulate the expression of bcl-2 and bax by inhibiting NF-κB pathway; and inhibit apoptosis in order to improve intestinal injury [74].