IL-38 is a cytokine of the IL-1 family that regulates the NOD-like receptor thermal-protein-domain-associated protein 3 (NLRP3)/IL-1β signaling pathway, inhibits the activation of NLRP3 inflammasomes, enhances CD4 CD25 Treg cell immune function, reduces the expression of inflammatory mediators and pro-apoptotic proteins, attenuates early inflammatory response and apoptosis, improves the depletion of effector T cells during sepsis, and increases the survival rate of septic mice (>60%) [34,35]. Here, NLRP3 is linked to Sepsis.