FGF-2 improves blood coagulation and reduces the expression of TF and PAI1 in sepsis by inhibiting the protein kinase B (AKT)/mammalian target of rapamycin (mTOR)/p70 ribosomal protein subunit 6 kinase 1 (S6K1) phosphorylation. The gene discussed is AKT1; the disease is Sepsis.