miR-25-5p can improve brain injury caused by sepsis by inhibiting the thioredoxin-interacting protein TXNIP/NLRP3 pathway; reducing the levels of TXNIP, NLRP3, and cleaved caspase-1; and inhibiting the expression of inflammatory factors (such as IL-6, IL-1β, and TNF-α and peroxide). This evidence concerns the gene TXNIP and Sepsis.