By inhibiting the TLR4/NF-κB pathway, α-ch, a serine protease, reduces the levels of inflammatory cytokines IL-1β, IL-6, and TNF-α, and inhibits the expression levels of myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) in a cecum ligation and puncture (CLP)-induced sepsis mouse model. The gene discussed is IL1B; the disease is Sepsis.