HMOX1 and injury: FGF-19 can reduce the expression of linoleic acid (LA) and gamma linolenic acid, activate the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (HO-1) pathway, and inhibit the expression of iNOS, ROS, caspase-3, and cytochrome c, thereby alleviating lipid metabolism disorders, liver injury, and kidney injury in mice with LPS-induced sepsis [26].