As a possible mechanism of action for EMP 1 and 3 in ACC, cross-talk with the ErbB family receptors (ErbB-1 (HER1 or epidermal growth factor receptor, EGFR), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)) may exist. The gene discussed is ERBB4; the disease is adrenal cortex carcinoma.