Although allelic frequencies are not rare (0.114822 for rs6198, 0.279039 for rs1024611, and 0.444187 for rs2431697 by gnomAD, respectively), a poorer prognosis was observed among patients with PMF harboring both JAK2V617F and homozygous mutations of rs6198 locating at NR3C1 than those bearing wild-type NR3C1 [76], rs1024611 at CCL2 strongly correlated to the CCL2 expression and the myelofibrosis grade [77], and homozygous rs2431697 at miR-146a was associated with myelofibrosis progression [78]. The gene discussed is CCL2; the disease is myelofibrosis.