Pathologically, PSP can be described by the presence of 4-repeat (4R) tau inclusions such as neurofibrillary tangles, neuropil threads, tufted astrocytes, and oligodendroglial coiled bodies, predominantly found in basal ganglia, diencephalon, and brainstem, with prominent involvement of globus pallidus subthalamic nucleus and substantia nigra. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.