Recent research demonstrated that a significant proportion (26% to be exact) of patients with PSP, typically classified as tauopathy, had abnormal accumulations of TDP-43 in the limbic system, suggesting that pathological TDP-43 accumulation can also occur within this form of tauopathy and could contribute to hippocampal sclerosis within this form of PSP cases [92]. This evidence concerns the gene TARDBP and supranuclear palsy, progressive, 1.