In turn, the sialylated IgG and the desialylated IgG connects with ST6Gal1 (to add α-2,6-SIA) and Neu1 (to remove α-2,6-SIA) in B cells, respectively; this further stresses the importance of these enzymes in RA pathophysiology [13,14]. Here, ST6GAL1 is linked to rheumatoid arthritis.