Concerning the prediction of mortality, the best performance was observed for TNF-α, IL-8 and 32 and IP-10, which were significantly higher in non-survivors; even though this was not surprising, these results highlight how the onset of an inflammatory disequilibrium is crucial for the clinical course of COVID-19 and further confirm the potential role of these cytokines as early prognostic biomarkers for hospitalized patients. The gene discussed is TNF; the disease is COVID-19.