TLR8ko mice show salivary adenitis, cytokines and anti-SSA and anti-SSB autoantibodies, which were not present in TLR7/8KO mice, suggesting that these changes depend on TLR7, further confirming the important role of TLR7 signaling in the local and systemic manifestations of SS [21]. This evidence concerns the gene CALR and synovial sarcoma.