In publicly available datasets ATRX aberrations (including deep deletions or mutations) are reported in melanoma in general, with data suggesting a more favorable course for ATRX-unaltered cancer (according to cBioPortal database and Human Protein Atlas, accessed on 1 August 2023), although the data for ATRX-altered cases are limited, with a lack of specific information concerning the melanoma arising from different locations, especially mucosal melanoma. The gene discussed is ATRX; the disease is mucositis.