Nevertheless, as is described below,, another indication of the possible role of AQP1-Abs in both the CNS and RBCs dysfunction is the case of a patient with LETM/MS diagnosis and a history of alemtuzumab treatment, who developed autoimmune hemolytic anemia (AIHA) and a clinical relapse with activity on brain MRI while a high AQP1-Ab titer was measured [16]. This evidence concerns the gene AQP1 and autoimmune hemolytic anemia.