The detection of antibodies to AQP1 cytoplasmic side in patients with non-NMOSD phenotype (like the present three patients with MS-like lesions profile) further suggests that these antibodies are not disease relevant, which is in line with the inability of these antibodies to bind to AQP1 on the intact cells and therefore their potential inability to cause damage to AQP1. The gene discussed is AQP1; the disease is myeloid sarcoma.