GSN and neoplasm: In the oncology research field, Giampazolias et al. reported that secreted gelsolin suppresses the capability of cDC1s to recognize F-actin from necrotic cells via CLEC9A and to cross-present tumor antigens to CD8+ T cells via MHC-I by using gelsolin-deficient mice and by analyzing human cancer tissues (inverse correlation between gelsolin expression and patient survival; positive correlation between low gelsolin expression and patient survival with mutations in F-actin-binding proteins) (Figure 3) [55].