IL33 and granular corneal dystrophy type II: Hoppe et al. reported that mast cells initiate vascular changes (vasodilation, permeabilization, and neutrophil influx) by prompt degranulation in response to cell stress or damage via the ATP–P2X7 pathway (causing histamine-triggered edema) and the IL-33–ST2 (IL-33 receptor) pathway (causing efficient induction of neutrophil infiltration) using various murine ACD models (Figure 5) [85].