M2 macrophages can be subclassified into four types: M2a (IL-4 and IL-13 induced; CD163+ CD206+ CD369+), M2b (TLR agonists and IL-1 receptor agonists induced; CD86+; IL-10 production; also known as regulatory macrophages), M2c (induced by IL-10; IL-10 and TGF-β production; removal of apoptotic cells), and M2d (tumor-associated macrophages) [69]. This evidence concerns the gene CD86 and neoplasm.