MRGPRX2 and granular corneal dystrophy type II: They also reported that (3) a Mrgprb2-deficiency decreases pruritus in ACD nonclinical models and (4) the expression levels of PAMP1-20 (proadrenomedullin N-terminal 20 peptide; MRGPRX2 agonist) are elevated in skin lesions obtained from patients with ACD (N=11) (Figure 5) [82].