M1 macrophages contribute to ACD development in response to IFN-γ (possibly Th1 skewed), whereas M2 macrophages may contribute to ACD development in a Th2-skewed manner (possibly M2a) as well as suppressive effects on ACD (via IL-10 and Arg1; possibly M2b). The gene discussed is IL10; the disease is granular corneal dystrophy type II.