Suwanpradid et al. reported that (1) skin biopsies obtained from ACD patients express iNOS+ (inducible nitric oxide synthase; production of nitric oxide; possibly contributing to ACD associated inflammation) CD14+ M1 macrophages and Arg1+ (arginase 1; anti-inflammatory function) M2b macrophages and (2) iNOS contributes to ACD-associated inflammation in mice. This evidence concerns the gene NOS2 and granular corneal dystrophy type II.