KEAP1 and pulmonary arterial hypertension: The experimental model of PAH showed an increase in systemic and tissue OS markers (TAC and lipid peroxidation), which was associated with the increase in Keap1, the protein repressor of Nrf2 factor, and the master regulator of transcription of endogenous antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase, etc.)[2].