Based on ROC analysis (Figure 2B), from the routine markers, LDH (AUC-ROC: 0.903; p < 0.001), albumin (AUC-ROC: 0.823; p < 0.001), SOFA score (AUC-ROC: 0.803; p < 0.001), D-dimer (AUC-ROC: 0.733; p < 0.01), hs-CRP (AUC-ROC: 0.740; p < 0.01), lymphocyte count (AUC-ROC: 0.738; p < 0.01), ferritin (AUC-ROC: 0.703; p < 0.05), and IL-6 (AUC-ROC: 0.724; p < 0.01) had diagnostic capacities regarding the differentiation between patients with severe and mild ARDS. This evidence concerns the gene CRP and acute respiratory distress syndrome.