Furthermore, the ALDEFLUOR assay revealed that the proportion of ALDHhigh cells was decreased in the siOLR1 group, suggesting the critical role of OLR1 in regulating stemness properties in HNSCC (p < 0.01 and p < 0.05, respectively, Figure 8C,D). The gene discussed is OLR1; the disease is head and neck squamous cell carcinoma.