The observation that the actin-cytoskeleton linker protein ezrin was overexpressed in the resistant colon cancer cells motivated us to examine its possible involvement in mediating vemurafenib resistance in melanoma cells since the role of actin-cytoskeleton organisation and remodeling was previously demonstrated in transition to vemurafenib-resistant phenotype in BRAFV600E mutant melanoma in vitro [20,34]. This evidence concerns the gene EZR and melanoma.