Our findings thus indicating the role of ezrin as a novel target for chemosensitisation in BRAFV600E-mutated colon cancer may be particularly relevant in light of recent clinical evidence demonstrating short-term efficacy of clinically approved combination therapy with EGFR/BRAF inhibitors in BRAFV600E-mutant metastatic colorectal cancer patients due to rapid development of resistance [30], which necessitates the development of novel therapeutic strategies for BRAFV600E-mutated colon cancer. Here, EGFR is linked to metastatic colorectal cancer.