APOE and atherosclerosis: We found that the deficiency in caspase-1 in Tg26+/−/ApoE−/−/Casp-1−/− mice resulted in significantly fewer atherosclerosis plaques in the thoracic aorta (Figure 1A,C), but not in the entire aorta including the arch, thoracic, and abdominal aorta (Figure 1A,B), nor in the aortic root (Figure 1D–F).