TNFAIP3 and lymphopenia: However, it has been demonstrated that in mice, full depletion of A20 in hematopoietic stem cells (HSCs) and multipotent progenitors hampers the hematopoietic process and leads to the development of anemia and lymphopenia, a loss of HSC quiescence and an impairment of HSC reconstitution capacity [82,83].