The scope of the studies includes model experiments [68], an introduction or a correction of disease-associated mutations [69,70,71,72,73,74], the analysis of the function of individual genes (e.g., USP18 and LRRK2 [75,76] and the generation of transgenic macrophages and myeloid cell lines for cancer therapy [77,78]. The gene discussed is USP18; the disease is cancer.