The HLA-G 5′URR G010101c haplotype was overrepresented in tumors presenting high HLA-G expression (>50% of positive tumor cells in PTC specimens) (OR = 6.3125, 95% CI = 0.8189–48.6592, p = 0.0457), while the coding region G*01:01:02:01 haplotype was associated with low HLA-G expression (≤50%) (OR = 0.4783, 95% CI = 0.2752–0.8311, p = 0.0111). This evidence concerns the gene HLA-G and neoplasm.