In lean mice with NASH-HCC, variations in methylation were observed in the genes associated with cancer progression and prognosis, including HCC-related genes such as CHCHD2, FSCN1, and ZDHHC12, as well as the genes involved in lipid metabolism such as PNPLA6 and LDLRAP1 [69]. The gene discussed is ZDHHC12; the disease is hepatocellular carcinoma.