A case–control study revealed that Pg is an independent risk factor for stroke, and elevated levels of Pg antibodies in the serum are related to an increased risk of stroke with a multivariate OR of 1.63 (95% CI = 1.06–2.50) for males and an OR of 2.30 (95% CI = 1.39–3.78) for females [58]. The gene discussed is JUP; the disease is Stroke.