Simple effect analysis showed that ABCG1 gene expression in the brains of mice in the ADC group was significantly lower (p < 0.01) compared with that in the WTC group; moreover, aerobic exercise significantly increased ABCG1 gene expression in the brains of mice in the ADE group (p < 0.05) compared with that in the ADC group. This evidence concerns the gene ABCG1 and AIDS dementia complex.