CYP46A1 and acute disseminated encephalomyelitis: Simple effect analyses showed that CYP46A1 protein levels in the brains of mice in the ADC group were significantly lower (p < 0.01) compared with the WTC group; aerobic exercise significantly increased CYP46A1 protein levels in the brains of mice in the ADE group (p < 0.05) compared with the ADC group.