HMGCR and acute disseminated encephalomyelitis: Post-hoc analysis showed that HMGCR gene expression in the brains of mice in the ADC group was significantly decreased compared with mice in the WTC group (p < 0.01); moreover, aerobic exercise significantly increased HMGCR gene expression in the brains of mice in the ADE group compared with mice in the ADC group (p < 0.01).