Post-hoc analysis showed that the LRP1 protein content in the brains of mice in the ADC group was significantly lower (p < 0.05) compared with mice in the WTC group; moreover, aerobic exercise significantly increased the LRP1 protein content in the brains of mice in the ADE group compared with mice in the ADC group (p < 0.05). The gene discussed is LRP1; the disease is acute disseminated encephalomyelitis.