The role of ANKHD1-BP3 as an inhibitor of metastasis and invasion in uterine corpus endometrial carcinoma goes against the evidence of the role of ANKHD1, which is generally pro-proliferation, in other cancer types (such as breast cancer, renal cell carcinoma, leukaemia, etc.), for the first time suggesting the existence of ANKHD1 isoform-specific roles. The gene discussed is ANKHD1; the disease is breast carcinoma.