As mentioned above, ANKHD1 was identified in a screen for proteins which interact with SH2-containing protein–tyrosine phosphatase (SHP2), a tyrosine phosphatase overexpressed in primary leukaemia cells and leukaemic cell lines [60]—an interaction that demonstrated the role of ANKHD1 in leukaemia. Here, PTPN11 is linked to leukemia.