CFTR and cystic fibrosis: Given that the primary strategy by which to definitively treat the CF disease is to use personalized combinations of CFTR modulators able to specifically rescue the molecular and cellular defects of the specific CF-causing mutation, as the last task of our work, we analyzed the effect of VX445 administrated in a triple combination with the other correctors used in this study on the transportation capability of VX770 and forskolin-stimulated FRT and CFBE41O− cells.