At present, the most effective therapy for CF is represented by Kaftrio (branded as Trikafta in the USA), consisting of a combination of the potentiator VX770, which increases the open probability of the channel, with the two correctors VX661 and VX445 that synergistically help to drive the processing-defective CFTR from the ER to the PM [30]. Here, CFTR is linked to cystic fibrosis.